HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 60389Generated: October 26, 2026
N,N'-Dimethylethylenediamine → HCID 117949471, compound
https://huagongshe.com/reaction/60389
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(4-chlorophenyl)-5H-furo[3,2-c]pyridine-4-one | HCID 58015558 | — |
| Reactant | HCID 117949767 | HCID 117949767 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 117949471 | HCID 117949471 | 19,644.6% |
Reaction Steps
A mixture of 2-(4-chlorophenyl)furo[3,2-c]pyridin-4(5H)-one (100 mg), 2-((1RS,2SR)-2-(6-bromo-1-methyl-1H-benzimidazol-2-yl)cyclopropyl)propan-2-ol (151 mg), N,N′-dimethylethylenediamine (0.043 mL), copper(I) iodide (78.0 mg), potassium carbonate (169 mg) and DMSO (3.0 mL) was heated at 190° C. for 1 hr under microwave irradiation. The reaction mixture was purified by silica gel column chromatography (NH, ethyl acetate/hexane), and the obtained solid was washed with ethyl acetate to give the title compound (37.9 g) as a pale red solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09440987B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-2201ed1237044b52bbc8fdc97f86485f |
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| Source note | uspto-grants-2016_09 |
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