反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 90 °C
PROCEDURE
实验过程
tert-Butyl (4-{(1R,2R)-2-({[2-(1,3-benzodioxol-5-yl)-5,5-dimethyl-1,3-dioxan-2-yl]methyl}thio)-1-[(4-methylphenyl)amino]-3-oxo-3-[(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]propyl}phenoxy)acetate (Method 20) (1.70 g, 2.03 mmol) was dissolved in dry toluene (200 mL) and heated to 90° C. under inert atmosphere. N,O-Bis(trimethylsilyl)acetamide (BSA, 1.50 mL, 6.10 mmol) was added and the mixture was stirred at 90° C. for one hour. The mixture was then given 45° C. and tetrabutylammonium fluoride (TBAF, cat., 0.1 g) was added and the mixture was stirred at 45° C. for 19 hours. The mixture was then concentrated under reduced pressure and purified by flash-chromatography (heptane:EtOAc 4:1). This afforded the title compound.
WORKUP
后处理
- customwas then given 45° C.
- stirringthe mixture was stirred at 45° C. for 19 hours
- concentrationThe mixture was then concentrated under reduced pressure
- custompurified by flash-chromatography (heptane:EtOAc 4:1)