3-Nitro-2-pyridinesulfenyl → tert-Butyl (4-{(2R,3R)-1-(4-chlorophenyl)-3-[(3-nitropyridin-2-yl)dithio]-4-oxoazetidin-2-yl}phenoxy)acetate

Participants

Reaction Conditions

Reaction Steps

tert-Butyl (4-{(2R,3R)-1-(4-chlorophenyl)-3-[(4-methoxybenzyl)thio]-4-oxoazetidin-2-yl}phenoxy)acetate (Method 26) (0.9 g, 1.7 mmol) was dissolved in CH2Cl2 (50 mL) and given 0° C. under inert atmosphere. 3-Nitro-2-pyridinesulfenyl chloride (0.4 g, 2.0 mmol) was added and the mixture was stirred for 30 minutes at 0° C., then 30 minutes at room temperature. Concentration under reduced pressure and purification by flash-chromatography (Heptane:EtOAc 3:1 then 2:1) afforded the title compound.

Provenance & Evidence