HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon tetrabromide → 5-(Bromomethyl)-2,3-dichloropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | 1,3-Bis(diphenylphosphino)propane | HCID 81219 | — |
| Reactant | (5,6-Dichloropyridin-3-yl)methanol | HCID 21882961 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(Bromomethyl)-2,3-dichloropyridine | HCID 21962328 | 130% |
Reaction Steps
5,6-dichloro-3-pyridinemethanol (1.0 eq.) was taken up in dichloromethane and stirred overnight with carbon tetrabromide (1.5 eq.) and 1,3-bis(diphenylphosphino)propane (0.75 eq.) Ether was added to the solution and filtration followed by concentration of the filtrate afforded the 5,6-dichloro-3-bromomethylpyridine in 130% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07906548B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-8a14207742734dabb64060f99264568b |
| Source note | uspto-grants-2011_03 |