2-Chlorobenzenesulfonyl chloride → HCID 21962279, compound

HRID 603963Notes

Reaction equation

HRID 603963 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[N:5]([CH:28]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:6]2[C:11]([C:12]=1[CH2:13][CH2:14][O:15][C:16]1[CH:25]=[CH:24][C:19]([C:20]([O:22]C)=[O:21])=[C:18]([F:26])[CH:17]=1)=[CH:10][C:9]([Cl:27])=[CH:8][CH:7]=2.[Cl:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=1[S:48](Cl)(=[O:50])=[O:49]>>[CH:28]([N:5]1[C:6]2[C:11](=[CH:10][C:9]([Cl:27])=[CH:8][CH:7]=2)[C:12]([CH2:13][CH2:14][O:15][C:16]2[CH:25]=[CH:24][C:19]([C:20]([OH:22])=[O:21])=[C:18]([F:26])[CH:17]=2)=[C:4]1[CH2:3][CH2:2][NH:1][S:48]([C:43]1[CH:44]=[CH:45][CH:46]=[CH:47][C:42]=1[Cl:41])(=[O:50])=[O:49])([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 761872-Chlorobenzenesulfonyl chlorideHCID 21962453methyl 4-{2-[2-(2-amino-ethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]-ethoxy}-2-fluoro-benzoate

Product 1

HCID 21962279HCID 21962279, compoundYield 73%

Procedure

The methyl 4-{2-[2-(2-amino-ethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]-ethoxy}-2-fluoro-benzoate from above and 2-chloro-benzenesulfonyl chloride were reacted according to the procedure in Example 1 Step 7 to generate the desired product in 73% yield.

Sources & evidence

ORD record
ord-7226cc1cf3914cd889f6a686774609ca
Source dataset
uspto-grants-2011_03
Patent number
US07906548B2

Reaction notes

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