反应详情

4-[2-(1-Benzhydryl-5-chloro-2-{2-[2-(2-methyl-penta-2,4-dienyloxy)-benzenesulfonylamino]-ethyl}-1H-indol-3-yl)-ethoxy]-benzoic acid (0.55 g, 0.70 mmole), (Step 1, Example 183) and 10% Pd/C (55 mg) in MeOH (30 ml) and EtOH (20 ml) was hydrogenated. The resulting mixture was filtered through Celite and concentrated. The residue was chromatographed with 3540% EtOAC/hexane to give the desired product (0.50 g, 95%).

1. filtrationThe resulting mixture was filtered through Celite
2. concentrationconcentrated
3. customThe residue was chromatographed with 3540% EtOAC/hexane