Sodium Hydroxide → HCID 87263149, compound

HRID 604038Notes

Reaction equation

HRID 604038 reaction equation
[F:1][C:2]([F:49])([F:48])[C:3]1[CH:4]=[C:5]([CH:41]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:43]=1)[CH2:6][N:7]([CH2:19][C:20]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:21]=1[N:30]([CH2:39][CH3:40])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][C:36]([OH:38])=[O:37])[C:8]1[N:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][O:17][CH3:18])=[CH:10][N:9]=1.[OH-].[Na+:51]>C(O)C>[Na+:51].[F:49][C:2]([F:1])([F:48])[C:3]1[CH:4]=[C:5]([CH:41]=[C:42]([C:44]([F:45])([F:46])[F:47])[CH:43]=1)[CH2:6][N:7]([CH2:19][C:20]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:21]=1[N:30]([CH2:39][CH3:40])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][C:36]([O-:38])=[O:37])[C:8]1[N:9]=[CH:10][C:11]([O:14][CH2:15][CH2:16][O:17][CH3:18])=[CH:12][N:13]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86626798HCID 86626798, compound

Product 1

HCID 87263149HCID 87263149, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6-{[2-({(3,5-Bis-trifluoromethyl-benzyl)-[5-(2-methoxy-ethoxy)-pyrimidin-2-yl]-amino}-methyl)-4-trifluoromethyl-phenyl]-ethyl-amino}-hexanoic acid (105 mg) is dissolved in ethanol (1 ml), and thereto is added a 2M-aqueous sodium hydroxide solution (74 μl), and the mixture is stirred at room temperature for 5 minutes. The reaction solution is concentrated under reduced pressure to give 6-{[2-({(3,5-bis-trifluoromethyl-benzyl)-[5-(2-methoxy-ethoxy)-pyrimidin-2-yl]-amino}-methyl)-4-trifluoromethyl-phenyl]-ethyl-amino}-hexanoic acid sodium salt (102 mg). MS (m/z): 709 [M−Na]−

Workup

  1. concentrationThe reaction solution is concentrated under reduced pressure

Sources & evidence

ORD record
ord-edd875099b1e4dd4b909279242656fcb
Source dataset
uspto-grants-2011_03
Patent number
US07906517B2

Reaction notes

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