HCID 86626878, compound → HCID 86626877, compound

Participants

Reaction Steps

Ethyl 4-(2-{(3,5-bis-trifluoromethyl-benzyl)-[2-(6-isopropenyl-3-methoxy-pyridin-2-yl)-5-trifluoromethyl-benzyl]-amino}-pyrimidin-5-yloxy)-butyrate (76 mg) is dissolved in ethanol (5 ml), and thereto is added 10% palladium-carbon (15 mg) and the mixture is stirred under hydrogen atmosphere for 1.5 hours. The catalyst is removed by filtration, and the filtrate is concentrated under reduced pressure to give ethyl 4-(2-{(3,5-bis-trifluoromethyl-benzyl)-[2-(6-isopropyl-3-methoxy-pyridin-2-yl)-5-trifluoromethyl-benzyl]-amino}-pyrimidin-5-yloxy)-butyrate (70 mg). MS (m/z): 759 [M+H]+

Provenance & Evidence