Sodium Hydroxide → 4-{5-[(3,5-Bis-trifluoromethyl-benzyl)-(5'-isopropyl-2'-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-amino]-tetrazol-2-yl}-butyric acid sodium salt

HRID 604144Notes

Reaction equation

HRID 604144 reaction equation
[F:1][C:2]([F:49])([F:48])[C:3]1[CH:4]=[C:5]([CH:41]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:43]=1)[CH2:6][N:7]([CH2:19][C:20]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:21]=1[C:30]1[CH:35]=[C:34]([CH:36]([CH3:38])[CH3:37])[CH:33]=[CH:32][C:31]=1[O:39][CH3:40])[C:8]1[N:9]=[N:10][N:11]([CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[N:12]=1.[OH-].[Na+:51]>C(O)C>[Na+:51].[F:47][C:44]([F:45])([F:46])[C:42]1[CH:41]=[C:5]([CH:4]=[C:3]([C:2]([F:1])([F:48])[F:49])[CH:43]=1)[CH2:6][N:7]([CH2:19][C:20]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:21]=1[C:30]1[CH:35]=[C:34]([CH:36]([CH3:37])[CH3:38])[CH:33]=[CH:32][C:31]=1[O:39][CH3:40])[C:8]1[N:9]=[N:10][N:11]([CH2:13][CH2:14][CH2:15][C:16]([O-:18])=[O:17])[N:12]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 866268904-{5-[(3,5-Bis-trifluoromethyl-benzyl)-(5'-isopropyl-2'-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-amino]-tetrazol-2-yl}-butyric acid

Product 1

HCID 872632204-{5-[(3,5-Bis-trifluoromethyl-benzyl)-(5'-isopropyl-2'-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-amino]-tetrazol-2-yl}-butyric acid sodium salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-{5-[(3,5-Bis-trifluoromethyl-benzyl)-(5′-isopropyl-2′-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-amino]-tetrazol-2-yl}-butyric acid (154 mg) is dissolved in ethanol (3 ml), and thereto is added 1M-aqueous sodium hydroxide solution (225 μl), and concentrated under reduced pressure to give 4-{5-[(3,5-bis-trifluoromethyl-benzyl)-(5′-isopropyl-2′-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-amino]-tetrazol-2-yl}-butyric acid sodium salt (153 mg). MS (m/z): 702 [M−Na]+

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-8e66a223e77b426da7cb8c39d4096c22
Source dataset
uspto-grants-2011_03
Patent number
US07906517B2

Reaction notes

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