Sodium Hydroxide → 4-(3-{[(5'-Isopropyl-2'-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-(5-morpholin-4-yl-pyrimidin-2-yl)-amino]-methyl}-5-trifluoromethyl-phenoxy)butyric acid sodium salt

HRID 604160Notes

Reaction equation

HRID 604160 reaction equation
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([O:52][CH3:53])=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=2[CH2:20][N:21]([CH2:34][C:35]2[CH:36]=[C:37]([CH:45]=[C:46]([C:48]([F:51])([F:50])[F:49])[CH:47]=2)[O:38][CH2:39][CH2:40][CH2:41][C:42]([OH:44])=[O:43])[C:22]2[N:27]=[CH:26][C:25]([N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)=[CH:24][N:23]=2)[CH:9]=1)([CH3:3])[CH3:2].[OH-].[Na+:55]>C(O)C>[Na+:55].[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([O:52][CH3:53])=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=2[CH2:20][N:21]([CH2:34][C:35]2[CH:36]=[C:37]([CH:45]=[C:46]([C:48]([F:51])([F:49])[F:50])[CH:47]=2)[O:38][CH2:39][CH2:40][CH2:41][C:42]([O-:44])=[O:43])[C:22]2[N:27]=[CH:26][C:25]([N:28]3[CH2:29][CH2:30][O:31][CH2:32][CH2:33]3)=[CH:24][N:23]=2)[CH:9]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 866268994-(3-{[(5'-Isopropyl-2'-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-(5-morpholin-4-yl-pyrimidin-2-yl)-amino]-methyl}-5-trifluoromethyl-phenoxy)butyric acid

Product 1

HCID 872631934-(3-{[(5'-Isopropyl-2'-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-(5-morpholin-4-yl-pyrimidin-2-yl)-amino]-methyl}-5-trifluoromethyl-phenoxy)butyric acid sodium salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(3-{[(5′-Isopropyl-2′-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-(5-morpholin-4-yl-pyrimidin-2-yl)-amino]-methyl}-5-trifluoromethyl-phenoxy)butyric acid (69 mg) is dissolved in ethanol (1 ml) and thereto is added a 1M-aqueous sodium hydroxide solution (92 μl) and the mixture is stirred at room temperature for 3 minutes, and concentrated under reduced pressure to give 4-(3-{[(5′-isopropyl-2′-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-(5-morpholin-4-yl-pyrimidin-2-yl)-amino]-methyl}-5-trifluoromethyl-phenoxy)butyric acid sodium salt (66 mg). MS (m/z): 745 [M−Na]+

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-bd7bd59e3e1547e189c822791bc1ebfe
Source dataset
uspto-grants-2011_03
Patent number
US07906517B2

Reaction notes

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