HCID 66602927, compound → HCID 23641323, compound

Participants

Reaction Steps

4-(2-{(3-Cyano-5-trifluoromethyl-benzyl)-[2-(6-isopropenyl-3-methoxy-pyridin-2-yl)-4,5-dimethoxy-benzyl]-amino}-pyrimidin-5-yloxy)-butyric acid (24.5 mg) is dissolved in methanol (2 ml), and thereto is added 10% palladium-carbon (10 mg) and the mixture is stirred under hydrogen atmosphere at room temperature for 1 hour. The insoluble material is removed by filtration and the filtrate is concentrated under reduced pressure. The residue is purified by silica gel column chromatography (chloroform:methanol=100:0→85:15) to give 4-(2-{(3-cyano-5-trifluoromethyl-benzyl)-[2-(6-isopropyl-3-methoxy-pyridin-2-yl)-4,5-dimethoxy-benzyl]-amino}-pyrimidin-5-yloxy)-butyric acid (21 mg). MS (m/z): 680 [M+H]+

Provenance & Evidence