1-Methoxy-5-methyl-4-nitro-2-(trifluoromethyl)benzene → HCID 66603540, compound

HRID 604172Notes

Reaction equation

HRID 604172 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([N+:10]([O-])=O)=[CH:5][C:4]=1[C:13]([F:16])([F:15])[F:14]>CO.[C].[Pd]>[CH3:1][O:2][C:3]1[C:4]([C:13]([F:14])([F:16])[F:15])=[CH:5][C:6]([NH2:10])=[C:7]([CH3:9])[CH:8]=1

Participants

4

Reactant 1

HCID 404271411-Methoxy-5-methyl-4-nitro-2-(trifluoromethyl)benzene

Product 1

HCID 66603540HCID 66603540, compoundYield 104%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1-Methoxy-5-methyl-4-nitro-2-trifluoromethyl-benzene (10 g) is dissolved in methanol (100 ml), and thereto is added 10% palladium-carbon (1 g) and the mixture is stirred under hydrogen atmosphere at room temperature for 1 day. The catalyst is removed by filtration, and the filtrate is concentrated under reduced pressure to give 4-methoxy-2-methyl-5-trifluoromethyl-phenylamine (9.07 g). MS (m/z): 206 [M+H]+

Workup

  1. customThe catalyst is removed by filtration
  2. concentrationthe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-337821e94bd642568e973f857ab596ec
Source dataset
uspto-grants-2011_03
Patent number
US07906517B2

Reaction notes

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