Ethyl Acetate → HCID 67087250, compound

Participants

Reaction Steps

2-Benzyloxy-5-trifluoromethoxy-benzaldehyde (1.40 g) is dissolved in ethanol (30 ml) and thereto is added sodium borohydride (189 mg) and the mixture is stirred at room temperature for 30 minutes. To the reaction solution are added aqueous ammonium chloride solution and ethyl acetate and the mixture is separated, and the organic layer is washed with a saturated brine, dried over magnesium sulfate and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (hexane:ethyl acetate=9:1→4:1) to give (2-benzyloxy-5-trifluoromethoxy-phenyl)methanol (1.10 g).

Provenance & Evidence