Water → HCID 57696171, compound

Participants

Reaction Steps

Water (0.1 mL) and 2.7 mg of lithium hydroxide hydrate (0.0643 mmol) were added to a solution of 22.5 mg of 2-furoyl-β-cyclohexyl-L-alanyl-glycyl-glycine ethyl ester (0.0552 mmol) in tetrahydrofuran (0.2 mL). After stirring for 1 hour at room temperature, water-ethanol (1:10, 0.5 mL) and 48.1 mg of IRC-50 (about 0.48 mg equivalent) were added and the mixture was stirred for 0.5 hour. IRC-50 (0.3 mg) was swelled in water-ethanol (1:10), and filled in a glass tube, and the mixture was placed on the column, and then the column was eluted by water-ethanol (1:10, 7.5 mL). The eluate was concentrated under reduced pressure, whereby 20.3 mg of the title compound was obtained as a colorless oil.

Provenance & Evidence