Hydrogen chloride-ethyl acetate → HCID 57696172, compound

Participants

Reaction Steps

To a solution (0.5 mL) of 233.3 mg of N-t-butoxycarbonyl-β-cyclohexyl-L-alanine 2-(1-piperidinyl)ethyl amide (0.611 mmol) in ethyl acetate, 1.5 mL of 4 M hydrogen chloride/ethyl acetate solution (6 mmol) was added and the reaction mixture was stirred for 4.5 hours at room temperature. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on alumina [alumina 2.5 g, methanol-chloroform (1:5)], whereby 167.7 mg of the title compound (97%) was obtained as a colorless oil (yield 97%).

Provenance & Evidence