反应详情

温度

80 °C

A mixture of 4-fluoro-2-methoxy-1-nitrobenzene (1.02 g, 5.97 mmol), [4,4′]bipiperidinyl (3.6 g, 14.9 mmol), 2N sodium hydroxide (30 mL), toluene (15 mL) and n-butylammonium bromide (96 mg, 0.30 mmol) is vigorously stirred at 80° C. for 18 hours. After 10 mL of water is added, the mixture is filtrated. The residue is washed with water and then dried to give 1-(3-methoxy-4-nitro-phenyl)-[4,4′]bipiperidine (1.79 g, 94% yield) as yellow solids.

1. filtrationthe mixture is filtrated
2. washThe residue is washed with water
3. customdried