Hydrochloric Acid → HCID 25222170, compound

Participants

Reaction Steps

methyl 3-(cyclopropylamino)-5-phenylpyrimido[4,5-c]quinoline-8-carboxylate (1.0 eq, 81 mg, 0.219 mmol) was stirred in EtOH (3 ml) and 6N NaOH (1 ml) at 60° C. for 15 hours. Water was added and the mixture acidified using 6 N HCl. The solid was filtered, washed with water and dried. After trituration in MeOH and filtration, 3-(cyclopropylamino)-5-phenylpyrimido[4,5-c]quinoline-8-carboxylic acid was isolated as yellow solid (57 mg, 73% yield)). LCMS (ES): >95% pure, m/z 357 [M+1]+.

Provenance & Evidence