HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 604377Generated: October 30, 2026
2-Oxobutanoic Acid → 1H-pyrazolo(3,4-b)pyridine
https://huagongshe.com/reaction/604377
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Oxobutanoic Acid | HCID 58 | — |
| Reactant | HCID 178418806 | HCID 178418806 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1H-pyrazolo(3,4-b)pyridine | HCID 2755850 | — |
Reaction Steps
In an alternative route, R2-aldehyde (II), 3-aminopyrazole (III) and R3-containing methyl pyruvic acid (V) are mixed in ethanol and heated to 50-120° C., preferably 60-100° C. Subsequent oxidization, preferably by exposure to air yields the 1H-Pyrazolo[3,4-b]pyridine acid derivative (VII).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07910602B2 |
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| Source dataset | uspto-grants-2011_03 |
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| ORD ID | ord-32b8ff84b475428da8543b5207e62d50 |
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| Source note | uspto-grants-2011_03 |
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