化工社化工社 化学情報印刷レポート · 研究参考用
15-Crown-5 → Pitolisant
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 15-Crown-5 | HCID 36336 | — |
| 反応物 | HCID 23694275 | HCID 23694275 | — |
| 反応物 | 3-(4-Chlorophenyl)propylmesylate | HCID 131726225 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Pitolisant | HCID 9948102 | — |
反応手順
Sodium 3-piperidinopropanolate (20 mmol), 7 mmol of 3-(4-chlorophenyl)propyl-mesylate, and 0.5 mmol of 15-crown-5 in 30 ml of dry toluene were refluxed for 4 hours. The solvent was evaporated and the residue purified by column chromatography on silica gel (eluent: methylene chloride/methanol (90/10)). After removing the solvent under reduced pressure the residue was crystallized with oxalic acid from diethyl ether/ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07910605B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-14df9569460c47b39eb0a92eb931fd54 |
| 出典メモ | uspto-grants-2011_03 |