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HRID6044

反应详情

EQUATION

反应方程式

HRID 6044 的结构方程式

REACTANTS

反应物

2
结构：N#Cc1cccc(O)c1
HCID13394

m-Hydroxybenzonitrile

C7H5NO

结构：CC(=O)O[C@H]1[C@H](OC(C)=O)CSC(Br)[C@@H]1OC(C)=O
HCID11382683

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)CS[C@H]1Oc1cccc(C#N)c1
HCID15067856

未命名化合物

收率 25%

AUXILIARIES

试剂、催化剂与溶剂

3
结构：[O-2].[Zn+2]
催化剂HCID3007857

Zinc oxide

OZn

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

If the procedure described in Preparation LXXVIII is followed starting from 0.5 g (1.4.10-3 mol) of 2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide, 0.25 g (2.1.10-3 mol) of 3-hydroxybenzonitrile and 170 mg (2.1.10-3 mol) of zinc oxide (ZnO) in 4 ml of anhydrous toluene and 4 ml of acetonitrile, 138 mg (yield: 25%) of the expected product are obtained after purification by chromatography on silica gel using a hexane/ethyl acetate mixture (2/1 v/v) as the eluent, and precipitation in ether.

WORKUP

后处理

  1. customIf the procedure described in Preparation LXXVIII