反应详情

1.0 g (5.5 mmol) of 5-propyl-2H-pyrazole-3-carboxylic acid ethyl ester was dissolved in 15 ml of dichloromethane and 1.23 g (5.5 mmol) of N-iodosuccinimide was added. The resulting solution was stirred at room temperature for 16 h. The solution was washed with aqueous sodium thiosulfate solution. The organic phase was dried with sodium sulfate and filtered. The resulting solution was passed through a short silica gel column, washing with dichloromethane. The solvent was removed under reduced pressure.

1. washThe solution was washed with aqueous sodium thiosulfate solution
2. dry with materialThe organic phase was dried with sodium sulfate
3. filtrationfiltered
4. washwashing with dichloromethane
5. customThe solvent was removed under reduced pressure