N-Iodosuccinimide → HCID 178470418, compound

HRID 604412Notes

Reaction equation

HRID 604412 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][N:8]=[C:9]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=1)=[O:5])[CH3:2].[I:16]N1C(=O)CCC1=O>ClCCl>[CH2:1]([O:3][C:4]([C:6]1[NH:7][N:8]=[C:9]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)[C:10]=1[I:16])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 178468642HCID 178468642, compound

Product 1

HCID 178470418HCID 178470418, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.0 g (4.5 mmol) of 5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid ethyl ester was dissolved in 15 ml of dichloromethane and 1.01 g (4.5 mmol) of N-iodosuccinimide was added. The resulting solution was stirred at room temperature for 16 h. The solution was washed with aqueous sodium thiosulfate solution. The organic phase was dried with sodium sulfate and filtered. The resulting solution was passed through a short silica gel column, washing with dichloromethane. The solvent was removed under reduced pressure.

Workup

  1. washThe solution was washed with aqueous sodium thiosulfate solution
  2. dry with materialThe organic phase was dried with sodium sulfate
  3. filtrationfiltered
  4. washwashing with dichloromethane
  5. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-d8ea300929e9462797a1de4266958050
Source dataset
uspto-grants-2011_03
Patent number
US07910606B2

Reaction notes

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