反应详情

A solution of 550 mg 4-Furan-2-yl-2,4-dioxo-butyric acid ethyl ester and 601 mg [5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-hydrazine in 10 ml acetic acid was heated to 80° C. for 2 h. Then the reaction mixture was diluted with 20 ml water and extracted with ethyl acetate (3×100 ml). The combined organic layers were dried over MgSO4. The solvents were removed under reduced pressure and the residue was purified by silica gel chromatography eluting with a n-heptane:ethyl acetate gradient 100%->50%.

1. extractionextracted with ethyl acetate (3×100 ml)
2. dry with materialThe combined organic layers were dried over MgSO4
3. customThe solvents were removed under reduced pressure
4. customthe residue was purified by silica gel chromatography
5. washeluting with a n-heptane