反应详情

A solution of 2 g Prop-2-yn-1-ol and 3 g Ethyl diazoacetate in 16 ml trichloromethane was stirred at 70° C. for 24 h. Then the solvent was removed under reduced pressure and the residue was purified on silica gel eluting with a gradient n-heptane/ethyl acetate 1:1->1:2. The fractions containing the product were collected and evaporated under reduced pressure.

1. customThen the solvent was removed under reduced pressure
2. customthe residue was purified on silica gel eluting with a gradient n-heptane/ethyl acetate 1:1->1:2
3. additionThe fractions containing the product
4. customwere collected
5. customevaporated under reduced pressure