Propargyl alcohol → HCID 178469099, compound

HRID 604452Notes

Reaction equation

HRID 604452 reaction equation
[CH2:1]([OH:4])[C:2]#[CH:3].[N+:5](=[CH:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N-:6]>ClC(Cl)Cl>[CH2:11]([O:10][C:8]([C:7]1[NH:5][N:6]=[C:2]([CH2:1][OH:4])[CH:3]=1)=[O:9])[CH3:12]

Participants

4

Reactant 2

HCID 7859Propargyl alcoholHCID 12192Ethyl diazoacetate

Product 1

HCID 178469099HCID 178469099, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 2 g Prop-2-yn-1-ol and 3 g Ethyl diazoacetate in 16 ml trichloromethane was stirred at 70° C. for 24 h. Then the solvent was removed under reduced pressure and the residue was purified on silica gel eluting with a gradient n-heptane/ethyl acetate 1:1->1:2. The fractions containing the product were collected and evaporated under reduced pressure.

Workup

  1. customThen the solvent was removed under reduced pressure
  2. customthe residue was purified on silica gel eluting with a gradient n-heptane/ethyl acetate 1:1->1:2
  3. additionThe fractions containing the product
  4. customwere collected
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-2c3b11bf58a646f7bf7e96743134ced6
Source dataset
uspto-grants-2011_03
Patent number
US07910606B2

Reaction notes

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