Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 2-(2-Furanyl)-1-phenylethanone | HCID 11735585 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 57709600 | HCID 57709600 | — |
Reaction Steps
2-Furan-2-yl-1-phenyl-ethanone (14.0 g, 75 mmol) and thiourea (11.5 g, 150 mmol) was dissolved in DMF (30 mL) and iodine (19.1 g, 75 mmol) was added. The reaction mixture was heated at 100° C. overnight, then diluted with water, made alkaline with saturated aqueous NH4OH, and extracted with ether. The organic phases were washed with water, dried over sodium sulfate, filtered, concentrated and purified by flash column chromatography using 1% ethyl acetate in hexane as eluent. Yield: 9.2 g, 45%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07910613B2 |
|---|
| Source dataset | uspto-grants-2011_03 |
|---|
| ORD ID | ord-6534b0dfa4234caaa8bd9cce72582754 |
|---|
| Source note | uspto-grants-2011_03 |
|---|
