反应详情

10% Palladium-carbon (500 mg, 50% hydrous) was suspended in ethanol (10 mL) and a solution of (4R)-4-methyl-4-[2-(1-ethylpyrrol-2-yl)ethenyl]-1,3-oxazolidin-2-one (5.7 g, 25.9 mmol) obtained in Reference example 3 (3c) in ethanol (50 mL) was added thereto, followed by stirring of the mixture at room temperature under a hydrogen atmosphere for 1 hour. After the palladium-carbon in the reaction mixture was Celite-filtered, the filtrate was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane: ethyl acetate, 3:7) to obtain the title compound (5.0 g, yield: 87%).

1. additionwas added
2. filtrationAfter the palladium-carbon in the reaction mixture was Celite-filtered
3. customthe filtrate was evaporated under reduced pressure
4. customThe residue was purified by silica gel chromatography (hexane: ethyl acetate, 3:7)