Iodine → 1-Fluoro-4-iodo-2-isopropyl-5-methoxybenzene

HRID 604597Notes

Reaction equation

HRID 604597 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]([CH3:12])=[CH2:11].[H][H].[I:15]I>CO.[Pd].S([O-])([O-])(=O)=O.[Ag+2]>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([I:15])=[CH:4][C:3]=1[CH:10]([CH3:12])[CH3:11]

Participants

7

Reactant 3

HCID 807IodineHCID 53363740Benzene, 2-fluoro-4-methoxy-1-(1-methylethenyl)-HCID 178418361HCID 178418361, compound

Product 1

HCID 533637411-Fluoro-4-iodo-2-isopropyl-5-methoxybenzene

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 178418844HCID 178418844, compoundCatalystHCID 887MethanolSolvent2×

Procedure

A solution of 2-fluoro-1-isopropenyl-4-methoxybenzene (1.96 g, 11.81 mmol) in CH3OH (30 mL) was charged with hydrogen at 1 atm with catalytic amount of palladium on carbon. The mixture was stirred at room temperature for 1 h. The mixture was filtered through Celite. The filtrate was then added to a mixture of silver sulfate (3.68 g, 11.81 mmol) and iodine (3.00 g, 11.81 mmol) in CH3OH (10 mL). The mixture was stirred at room temperature for 3 h until the color of solution became light yellow. The mixture was filtered and the filtrate was concentrated. The title compound was obtained after flash chromatography using EtOAc:hexane 5:95 as the eluant. 1H NMR (CDCl3, 500 MHz) δ 7.61 (d, J=8.0 Hz, 1H), 6.56 (d, J=12.5 Hz, 1H), 3.90 (s, 3H), 3.18 (m, 1H), 1.28 (m, 6H).

Workup

  1. filtrationThe mixture was filtered through Celite
  2. stirringThe mixture was stirred at room temperature for 3 h until the color of solution
  3. filtrationThe mixture was filtered
  4. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-4da91a92522346589275bf841a471bed
Source dataset
uspto-grants-2011_03
Patent number
US07910592B2

Reaction notes

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