p-Toluenesulfonic acid → HCID 67057742, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 6-(4-fluoro-5-isopropyl-2-methoxyphenyl)-3-hydroxy-3-methylindane-5-carboxylate (22.6 mg, 0.061 mmol) in toluene (1 mL) at room temperature was added TsOH (5.8 mg, 0.030 mmol). The reaction mixture was heated at 80° C. for 1.5 h. The reaction mixture was diluted with EtOAc. The organic layer was washed consecutively with sat. aq. NaHCO3 (1×) and brine (1×), dried (Na2SO4), filtered and concentrated in vacuo to give methyl 6-(4-fluoro-5-isopropyl-2-methoxyphenyl)-3-methyl-1H-indene-5-carboxylate. LCMS calc.=377.2; found=376.9 (M+Na)+. 1H NMR (500 MHz, CDCl3): δ 7.85 (s, 1H); 7.41 (s, 1H); 7.14 (d, J=8.7 Hz, 1H); 6.63 (d, J=12.1 Hz, 1H); 6.30 (t, J=1.5 Hz, 1H); 3.72 (s, 3H); 3.72 (s, 3H); 3.42 (d, J=1.5 Hz, 2H); 3.29-3.21 (m, 1H); 2.25 (s, 3H); 1.31 (d, J=6.9 Hz, 6H).

Provenance & Evidence