HCID 24969814, compound → HCID 24969815, compound

Participants

Reaction Steps

A suspension of 10% palladium on carbon (4.0 mg) in a solution of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[3-(4-fluoro-5-isopropyl-2-methoxyphenyl)-5-nitro-2-naphthyl]methyl}-4-methyl-1,3-oxazolidin-2-one (21.3 mg, 0.0321 mmol) in EtOAc (2.5 mL) was stirred under H2 (double balloon pressure) overnight. The reaction mixture was filtered through a plug of Celite and the filtrate was concentrated in vacuo to afford (4S,5R)-3-{[5-amino-3-(4-fluoro-5-isopropyl-2-methoxyphenyl)-2-naphthyl]methyl}-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one. LCMS calc.=635.2; found=634.8 (M+1)+.

Provenance & Evidence