Sulfuric Acid → HCID 67057766, compound

Participants

Reaction Steps

To a solution of 8-(3-chloro-4-fluorophenyl)-1,4-dioxaspiro[4.5]decane (401.7 mg, 1.484 mmol) in acetone (6 ml) was added 1M sulfuric acid (24 ml, 24 mmol). The reaction was stirred vigorously at room temperature for 18 hours, and then diluted with EtOAc (100 mL) and washed with water (3×50 mL), saturated NaHCO3 (2×50 mL), and brine (2×50 mL). The organic layer was dried (Na2SO4), filtered, and concentrated to afford 4-(3-chloro-4-fluorophenyl)cyclohexanone. 1H NMR (500 MHz, CDCl3): δ 7.06-7.28 (m, 3H), 3.00 (m, 1H), 2.49-2.52 (m, 4H), 2.19-2.23 (m, 2H), 1.85-1.93 (m, 2H).

Provenance & Evidence