Potassium Hydroxide → {3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-cyclopropylpyridin-3-yl]-4-methoxyphenyl}acetic acid

Participants

Reaction Steps

To a solution of methyl {3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-cyclopropylpyridin-3-yl]-4-methoxyphenyl}acetate (43 mg, 0.069 mmol) in MeOH (4 mL) was added 4M KOH (200 μL, 0.8 mmol). The reaction was stirred at room temperature for 4 hours and then quenched with HOAc (75 μL), diluted with EtOAc (30 μL), and washed with water and brine (10 mL each). The organic layer was dried (Na2SO4), filtered, and concentrated. Purification of the residue by flash chromatography on silica gel (0 to 100% EtOAc/hexanes) afforded {3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-cyclopropylpyridin-3-yl]-4-methoxyphenyl}acetic acid. LCMS=609.4 (M+H)+. 1H NMR (500 MHz, CDCl3): δ 7.84 (s, 1H), 7.72 (s, 2H), 7.39 (d, J=7.8 Hz, 1H), 7.27 (m, 1H), 7.14 (d, J=7.8 Hz, 1H), 7.07 (bs, 1H), 6.93 (d, J=8.5 Hz, 1H), 5.53 (bs, 1H), 4.85 (d, J=16.0 Hz, 1H), 3.86-4.20 (m, 2H), 3.78 (s, 3H), 3.61 (s, 2H), 2.07 (m, 1H), 1.00-1.10 (m, 4H), 0.54-0.70 (m, 3H).

Provenance & Evidence