反应详情

温度

60 °C

To a solution of 6-(4-chlorophenoxy)-5-((4-fluorophenyl)(hydroxy)methyl)-1-methyl-3-(3-(tetra hydro-2H-pyran-2-yloxy)propyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (55 mg, 0.10 mmol) in HCOOH (3 mL) was added Zn dust (40.4 mg, 0.62 mmol). The reaction was heated at 60° C. for 2 h then cooled to RT and filtered. The filtrate was concentrated to give 3-((6-(4-chlorophenoxy)-5-(4-fluorobenzyl)-1-methyl-2,4-dioxo-1,2-dihydropyrido[2,3-d]pyrimidin-3(4H)-yl)propylformate (50 mg, 100% yield) as a white solid. LCMS: MH+ 498 and TR=1.732 min. Used without further purification.

1. temperaturethen cooled to RT
2. filtrationfiltered
3. concentrationThe filtrate was concentrated