反应详情

温度

100 °C

To a solution of oleyl bromide (1.8 g, 5.4 mmol) in cyclohexanone (20 ml) was added protocatachualdehyde (0.341 g, 2.5 mmol), potassium carbonate (1.02 g, 7.4 mmol) and potassium iodide (0.05 g, 0.3 mmol). The suspension was stirred at 100° C. for 18 hours under nitrogen. Due to the light sensitivity of the oleyl bromide the flask was covered in aluminum foil. TLC (10% MeOH/CHCl3) showed the reaction was complete. The hot reaction mixture was filtered to remove some of the particulates and the solvent was removed in vacuo. The residue was dissolved in CHCl3 (100 mL) and washed with water (2×75 mL). The CHCl3 layer was dried over anhydrous sodium sulphate, filtered and the solvent removed in vacuo to give a dark yellow oil. The oily residue was purified by flash column chromatography (5% EtAc/hexane) to yield the product 8a as a white solid (1.08 g, 69%), Rf=0.3 (5% EtAc/hexane). 1H NMR (CDCl3) d 9.80 (s, 1H, CHO), 7.37 (m, 2H, phenyl), 6.93 (d, 1H, phenyl), 5.33 (t, 4H, olefinic), 4.06 (t, 2H, OCH2), 4.04 (t, 2H, OCH2), 2.01 (m, 8H, CH2C═C), 1.85 (m, 4H, CH2CH2O), 1.50-1.18 (m, 44H, 22×CH2), 0.88 (t, 6H, CH3); 13C NMR (CDCl3) d 191.00, 155.34, 149.95, 130.14, 130.12, 129.97, 126.79, 111.89, 111.04, 69.36, 32.29, 30.16, 29.92, 29.90, 29.88, 29.72, 29.64, 29.62, 29.44, 29.36, 27.60, 26.37, 26.34, 23.09, 14.53; HRMS (FAB): theory for C43H75O3 (M+1), 639.5716; found (M+1), 639.5755. Anal. (C43H74O3): C, H.

1. filtrationThe hot reaction mixture was filtered
2. customto remove some of the particulates
3. customthe solvent was removed in vacuo
4. dissolutionThe residue was dissolved in CHCl3 (100 mL)
5. washwashed with water (2×75 mL)
6. dry with materialThe CHCl3 layer was dried over anhydrous sodium sulphate
7. filtrationfiltered
8. customthe solvent removed in vacuo
9. customto give a dark yellow oil
10. customThe oily residue was purified by flash column chromatography (5% EtAc/hexane)