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HRID6048

反应详情

EQUATION

反应方程式

HRID 6048 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)c1ccccc1O
HCID8375

2-Hydroxyacetophenone

C8H8O2

结构：CC(=O)O[C@H]1[C@H](OC(C)=O)CSC(Br)[C@@H]1OC(C)=O
HCID11382683

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)CS[C@H]1Oc1ccccc1C(C)=O
HCID15067860

未命名化合物

收率 13.5%

AUXILIARIES

试剂、催化剂与溶剂

4
结构：[Cl-].[Cl-].[Zn+2]
催化剂HCID3007855

Zinc chloride

Cl2Zn

结构：[Ag+].c1c[n-]cn1
催化剂HCID10931941

未命名化合物

结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

If the procedure described in Preparation LXXXIII is followed starting from 3.45 g (25.3.10-3 mol) of 1-(2-hydroxyphenyl)ethanone, 6 g (16.9.10-3 mol) of 2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide, 3 g (17.10-3 mol) of silver imidazolate and 4.6 g (33.7.10-3 mol) of zinc chloride in 90 ml of methylene chloride and 30 ml of acetonitrile, 0.92 g (yield: 13.5%) of the expected product is obtained after purification by chromatography on silica gel using a toluene/ethyl acetate mixture (6/1 v/v) as the eluent, and crystallization from ether.

WORKUP

后处理

  1. customIf the procedure described in Preparation LXXXIII