反应详情

3-Isobutyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]aniline (1.6 g, 5 mmol) was dissolved in a 28% by weight methanol solution (9.6 g) of sodium methoxide and stirred under heating for 3 hours. After cooling, the reaction solution was poured into ice water, followed by extracting with ethyl acetate and washing with water. The solution was dried over magnesium sulfate and concentrated under reduced pressure, and then the residue was purified by using silica gel chromatography (hexane:ethyl acetate=5:1) to obtain 1.31 g of the desired compound.

1. temperatureunder heating for 3 hours
2. temperatureAfter cooling
3. extractionby extracting with ethyl acetate
4. washwashing with water
5. dry with materialThe solution was dried over magnesium sulfate
6. concentrationconcentrated under reduced pressure
7. customthe residue was purified