Benzenesulfonic Acid → HCID 11670737, compound

Participants

Reaction Steps

To 1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine (300 mg, 0.846 mmol) were added methyl alcohol (2.5 mL) and benzenesulfonic acid (136 mg, 0.863 mmol) to form a thoroughly dissolved state, followed by concentration under reduced pressure. To the obtained residual oil was added ethyl acetate to dissolve, and the mixture was allowed to stand. The suspension containing precipitated crystals was concentrated to dryness under reduced pressure. Diethyl ether was added thereto, and the solid was triturated by sonication. Precipitated crystals were collected by filtration, washed with diethyl ether, and aircured by aspiration. Drying under reduced pressure using a vacuum pump at room temperature gave 425 mg of the title compound as colorless crystals.

Provenance & Evidence