Hydrochloric Acid → HCID 11718083, compound

Participants

Reaction Steps

1-Cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine (147 mg, 0.415 mmol) obtained in Example 2 was dissolve in dichloromethane (3 mL), and a 4N solution of hydrogen chloride in ethyl acetate (0.11 mL, 0.456 mmol) was added to the mixture under a nitrogen atmosphere. This was stirred at room temperature for 15 minutes, the solvent was removed under reduced pressure. To the obtained reside was added ethyl acetate (13 mL), followed by stirring at an external temperature of 100° C. for 1 hour to form a thoroughly dissolved state. Then this solution was allowed to cool down to room temperature, followed by stirring for 19 hours 45 minutes. Precipitated hydrochloride was collected by filtration to give 134 mg of the title compound as colorless crystals.

Provenance & Evidence