Phenylmethanesulfonyl chloride → [3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-(5-phenylmethanesulfonyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-amine

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The title compound was prepared in analogy to example 45 from 90 mg (0.2 mmol) [3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-amine trihydrochloride and 39 mg (0.2 mmol) alpha-toluenesulphonylchloride yielding 18 mg (18%) [3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-(5-phenylmethanesulfonyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-amine as a yellow solid. MS ISP (m/e): 496.1 (100) (M+H)+. 1H NMR (DMSO-D6, 250 MHz): δ (ppm)=10.36 (s, 1H), 7.64 (s, 1H), 7.47 (s, 1H), 7.38-7.35 (m, 6H), 7.30 (d, 1H), 7.25 (d, 1H), 7.02 (s, 1H), 4.50 (s, 2H), 4.29 (s, 2H), 3.78 (s, 3H), 3.48 (t, 2H), 2.64 (br t, 2H), 2.14 (s, 3H).

Provenance & Evidence