[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]thiourea → HCID 25106199, compound

Participants

Reaction Steps

The title compound was prepared in analogy to example 1 step e) from crude 2-chloro-1-(3-chloro-4-methyl-phenyl)-butan-3-one and 53 mg (0.2 mmol) [3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-thiourea in ethanol (1 ml). The crude product was purified on silica gel with methylene chloride/methanol 9/1 yielding 56 mg (64%) of the title compound as a brown solid. MS ISP (m/e): 439.3/440.3/441.2/442.2 (100/69/50/34) (M+H)+. 1H NMR (CDCl3, 300 MHz): δ (ppm)=7.62 (s, 1H), 7.18-7.15 (m, 3H), 7.13 (s, 1H), 6.98 (d, 1H), 6.88 (d, 1H), 6.85 (s, 1H), 3.91 (s, 2H), 3.83 (s, 3H), 2.33 (s, 3H), 2.28 (s, 3H), 2.27 (s, 3H).

Provenance & Evidence