[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]thiourea → HCID 25106200, compound

Participants

Reaction Steps

The title compound was prepared in analogy to example 1 step e) from crude 2-chloro-1-(3,4-dichloro-phenyl)-butan-3-one and 53 mg (0.2 mmol) [3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-thiourea in ethanol (1 ml). The crude product was purified on silica gel with methylene chloride/methanol 9/1 yielding 85 mg (93%) of the title compound as a brown solid. MS ISP (m/e): 4.59.3/461.2/460.3/462.2 (100/74/35/20) (M+H)+. 1H NMR (CDCl3, 300 MHz): δ (ppm)=7.63 (s, 1H), 7.37 (d, 1H), 7.27 (s, 1H), 7.21 (s, 1H), 7.15 (d, 1H), 7.03 (d, 1H), 6.89 (d, 1H), 6.86 (s, 1H), 3.93 (s, 2H), 3.83 (s, 3H), 2.29 (s, 3H), 2.27 (s, 3H).

Provenance & Evidence