2-Bromo-3'-chloro-4'-methylpropiophenone → [4-(3-Chloro-4-methyl-phenyl)-5-methyl-thiazol-2-yl]-[4-(4-methyl-imidazol-1-yl)-phenyl]-amine

Participants

Reaction Steps

Prepared in analogy to example 64d) from 100 mg (0.43 mmol) [4-(4-methyl-imidazol-1-yl)-phenyl]-thiourea (example 72c)) and 124 mg (0.47 mmol) 2-bromo-3′-chloro-4′-methylpropiophenone. 115 mg (68%) of the product was isolated as a colorless solid. MS ISP (m/e): 395.1 (100) (M+H)+. 1H NMR (DMSO-D6, 300 MHz): δ (ppm)=10.50 (s, 1H), 9.47 (s, 1H), 7.95 (s, 1H), 7.87 (d, 2H), 7.70-7.60 (m, 3H), 7.52 (d, 2H), 2.45 (s, 3H), 2.41 (s, 3H), 2.35 (s, 3H).

Provenance & Evidence