Peptide oostatic hormone → 1,3,5-Trimethoxy-2,4,6-trinitrobenzene

Participants

Reaction Steps

Alkoxylating the nitrated alkoxy derivatives forms 1,3,5-trialkoxy-2,4,6-trinitrobenzene, which remains dissolved in the organic solvent to form a 1,3,5-trialkoxy-2,4,6-trinitrobenzene/organic solvent solution. Additional organic solvent may, optionally, be added to maintain an initial volume of the organic solvent in the reaction vessel such that the 1,3,5-trialkoxy-2,4,6-trinitrobenzene remains in solution. For example, the additional organic solvent may be added to the reaction vessel to maintain a volume of from about 10 mL to about 50 mL. In one embodiment, TMOF is used as the alkoxylating agent and is reacted with the 5-methoxystyphnic acid or 3,5-dimethoxypicric acid, producing 1,3,5-trimethoxy-2,4,6-trinitrobenzene. While the example described herein utilizes TMOF as the alkoxylating agent, triethyl orthoformate or tripropyl orthoformate may be used to form 1,3,5-triethoxy-2,4,6-trinitrobenzene or 1,3,5-tripropoxy-2,4,6-trinitrobenzene, respectively.

Provenance & Evidence