反应详情

To a solution of the product of Example 8C (21 g, 0.093 mol) and liquid ammonia (250 mL) in 500 mL of ethanol were reacted in a sealed high-pressure vessel at 130° C. for 20 hours. The reaction mixture was concentrated under vacuum and the residue ground to a fine powder then washed with water (2×50 mL) and dried in a vacuum oven for 24 hours to provide the title compound as a beige solid (14 g, 93%).

1. concentrationThe reaction mixture was concentrated under vacuum
2. washthe residue ground to a fine powder then washed with water (2×50 mL)
3. customdried in a vacuum oven for 24 hours