HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-chloropyridine → {4-[2-Amino-4-(4-trifluoromethyl-thiazol-2-ylcarbamoyl)-phenylsulfanyl]-phenyl}-carbamic acid 9H-fluoren-9-ylmethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-chloropyridine | HCID 66174 | — |
| Reactant | 2-Thiazolamine, 4-(trifluoromethyl)- | HCID 1201417 | — |
| Reactant | HCID 86615543 | HCID 86615543 | — |
| Product | {4-[2-Amino-4-(4-trifluoromethyl-thiazol-2-ylcarbamoyl)-phenylsulfanyl]-phenyl}-carbamic acid 9H-fluoren-9-ylmethyl ester | HCID 86615544 | — |
Reaction Steps
A mixture of the product from Example 19C was reacted with 4-Trifluoromethyl-thiazol-2-ylamine using the procedure of Example 19D substituting 4-Trifluoromethyl-thiazol-2-ylamine for 5-chloro-2-aminopyridine followed by reduction of the nitro group following the procedure of Example 19E to provide the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07910595B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-1b09f50c9b944ff69d1eb4ef6e647ac0 |
| Source note | uspto-grants-2011_03 |