N'-(3-Cyano-6-methyl-pyridin-2-yl)-N,N-dimethyl-formamidine → HCID 67040209, compound

Participants

Reaction Steps

The product of Example 37C was reacted with the product of Example 9B using the procedure of Example 37D substituting the product of Example 9B for the product of Example 8E to provide the crude title compound which was purified by column chromatography on silica gel using methanol/dichloromethane as eluent to provide the title product (42 mg, 49%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 2.66 (s, 3 H) 6.75 (d, J=8.82 Hz, 2 H) 6.89 (t, J=8.27 Hz, 3 H) 7.53 (d, J=8.82 Hz, 3 H) 7.75 (d, J=9.19 Hz, 2 H) 7.86 (dd, J=8.64, 1.65 Hz, 1 H) 8.18 (d, J=1.47 Hz, 1 H) 8.61 (s, 1 H) 8.77 (d, J=8.46 Hz, 1 H) 9.39 (s, 1 H) 10.00 (s, 1 H) 10.30 (s, 1 H); MS (ESI+) m/z 542/544 (M+H)+.

Provenance & Evidence