Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

The product of Example 86E (305 mg, 0.504 mmol) was dissolved in dichloromethane (5 mL) and trifluoroacetic acid (2 mL). The solution was stirred at room temperature for 1 hour at which time the solvent was removed on the under vacuum. The resultant residue was purified by HPLC with TFA to provide the title compound as a trifluoroacetic acid salt (35 mg, 14%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.34 (d, J=6.99 Hz, 6 H), 2.28 (s, 3 H), 3.28 (qt, J=13.70, 6.94 Hz, 1 H), 6.82-6.88 (m, 2 H), 6.91-6.99 (m, 3 H), 7.16 (d, J=8.46 Hz, 2 H), 7.63 (d, J=8.46 Hz, 2 H), 7.86 (d, J=8.46 Hz, 1 H), 7.98 (dd, J=8.46, 2.21 Hz, 1 H), 8.13 (d, J=2.21 Hz, 1 H), 8.87 (s, 1 H), 8.98 (d, J=8.46 Hz, 1 H), 10.17 (s, 1 H); MS (ESI+) m/z 505 (M+H-TFA)+; (ESI−) m/z 503 (M−H-TFA)−.

Provenance & Evidence