Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

To a slurry of the product of Example 95D (0.67 g, 0.98 mmol) in dichloromethane (10 mL) was added dropwise trifluoroacetic acid (5 mL). The solution was stirred for 30 minutes and concentrated under vacuum. The resultant residue was purified by HPLC with TFA to provide the title compound as a trifluoroacetic acid salt (15 mg, 35%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.36 (d, J=6.62 Hz, 6 H), 3.22-3.33 (m, 1 H), 6.31-6.64 (m, 3 H), 6.97 (t, J=7.91 Hz, 1 H), 7.23-7.41 (m, 3 H), 7.69-7.79 (m, 1 H), 7.83 (d, J=9.56 Hz, 1 H), 7.91 (d, J=11.03 Hz, 1 H Hz, 1 H), 7.99 (s, 1 H), 8.07 (s, 1 H), 8.79 (s, 1 H), 8.95 (d, J=7.35 Hz, 1 H), 10.41 (s, 1 H), 11.40 (s, 1 H).

Provenance & Evidence