N'-(3-Cyano-6-methyl-pyridin-2-yl)-N,N-dimethyl-formamidine → HCID 67040342, compound

Participants

Reaction Steps

The product of Example 107B was reacted with the product from Example 9B using the procedure from Example 95D substituting the product from Example 107B for the product from Example 95C and substituting the product from Example 9B for the product from Example 8E to provide the crude product was purified by HPLC with NH4OH to provide the title compound (28 mg, 44%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.45 (s, 9 H), 2.66 (s, 3 H), 6.61 (d, J=8.09 Hz, 1 H), 7.04 (d, J=8.46 Hz, 1 H), 7.11-7.23 (m, 2 H), 7.25-7.39 (m, 3 H), 7.51 (d, J=8.46 Hz, 1 H), 7.71-7.80 (m, 1 H), 7.91 (dd, J=8.46, 2.21 Hz, 1 H), 8.09-8.12 (m, 1 H), 8.20 (d, J=1.84 Hz, 1 H), 8.60 (s, 1 H), 8.73 (d, J=8.46 Hz, 1 H), 9.44 (s, 1 H), 10.02 (s, 1 H), 10.36 (s, 1 H); MS (ESI+) m/z 641/643 (M+H)+.

Provenance & Evidence