Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

The product of Example 108 (0.028 g, 0.044 mmol) was treated with trifluoroacetic acid as in the procedure for Example 96. The crude product was purified by trituration in dichloromethane to give the title compound as a trifluoroacetic acid salt (0.025 g, 87%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 2.75 (s, 3 H), 6.24 (d, J=8.09 Hz, 1 H), 6.30 (s, 1 H), 6.39 (d, J=7.72 Hz, 1 H), 7.01 (t, J=7.91 Hz, 1 H), 7.12 (d, J=8.82 Hz, 1 H), 7.25-7.40 (m, 2 H), 7.69-7.78 (m, 1 H, 7.82 (d, J=8.82 Hz, 1 H), 8.03 (dd, J=8.64, 2.39 Hz, 1 H), 8.12 (dd, J=17.46, 2.02 Hz, 2 H), 8.88-9.00 (m, 2 H), 10.41 (s, 1 H), 11.60 (s, 1 H); MS (ESI+) m/z 541/543 (M+H)+.

Provenance & Evidence