反应详情

A solution of the product from Example 9B (340 mg, 1.80 mmol), and 4-(2-Amino-4-nitro-phenylsulfanyl)-phenol (480 mg, 1.80 mmol) in acetic acid (10 mL) was stirred in an oil bath preheated to 130° C. for 30 minutes. The mixture was then cooled to room temperature, the acetic acid removed under vacuum leaving a brown oil (4-[2-(7-Methyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-nitro-phenylsulfanyl]-phenol) (0.65 g, 89%).

1. customthe acetic acid removed under vacuum